角朊细胞凋亡与银屑病

Apoptosis of Keratinocytes and Psoriasis

为了探讨银屑病皮损表皮角朊细胞凋亡状况,采用末端标记技术研究寻常型银屑病不同阶段皮损表皮变化。结果显示早期鳞屑丘疹表皮角朊细胞凋亡发生率最高,进行性斑丘疹及融合性斑块依次递减,表皮过度增殖改变与其相反。本研究提示银屑病皮损表皮组织改变始发于角朊细胞凋亡异常增多,继而出现角朊细胞过度增殖。

In order to study the status of cell apoptosis in psoriatic epidermis, we have investigated the changes of the lesions in various stages in patients with psoriasis vulgaris by using terminal deoxynueleotidyl transferase-mediation dUTP-biotin nick end labelling (TUNEL). The results showed that the highest frequency of apoptotic keratinocytes was observed in the early scaling papular lesions, and the frequency was reduced in the progressive maculo-papular lesions and the coalescent plaques successively. The frequency of hyperproliferation of epidermis was in the reverse order in comparison with the above results. These results suggest that increased apoptosis of keratinocytes is the initial change of psoriatic epidermis, then hyperproliferation of keratinoeytes follows.