摘要
为了解高白细胞性急性白血病(HAL)的临床规律和预后因素。对244例HAL和同期非HAL进行回顾性对照分析。结果显示:发现HAL构成比为8.5%,HAL中急性淋巴细胞白血病(ALL)较多,在急性髓细胞白血病(AML)中M5占的比例最多,为40.5%。HAL发病时肝、脾、淋巴结肿大,DIC,中枢神经系统白血病(CNSL)较非HAL为多。完全缓解(CR)率为41.4%,低于非HAL的54.2%,早期病死率是23.8%。早期死亡的主要原因是颅内出血,占50%。早期死亡的高危因素有发病时Hb≤40g/L,血小板≤30×109/L,DIC,感染,CNSL。结果显示:HAL完全缓解率低,早期死亡率高,预后差,特别是HAL-AML的早期死亡率明显高于HAL-ALL,要重视其早期处理。
To know the clinical characteristics and the prognostic factors of hyperleukocytic acute leukemia, we reviewed 244 patients with acute leukemia associated with hyperleukocytosis. Restrospective analysis and control study were used. Hyperleukocytosis occured in 8.5% of patients with acute leukemia. Hyperleukocytosis in ALL was more common than that in AML. Among AML with hyperleukocytosis, M 5 subtype was the most. Hepatomegaly, splenomegaly, lymphadenopathy, DIC and CNSL were more frequent in hyperleukocytosis group. The complete remission rate was 41.4% for patients with hyperleukocytosis versus 54.2% for patients with non hyperleukocytosis. The early mortality rate was significantly increased in hyperleukocytic patients (23.8%) as compared to the nonhyperleukocytic group (11.1%). Intracranial hemorrhage was the main cause of early death. The high risk factors of early death were: hemoglobin≤40 g/L, blood platelet≤30×10 9/L, DIC, infection, CNSL at presentation. Acute leukemia with hyperleukocytosis has poor prognosis. Especially, acute myeloid leukemia with hyperleukocytosis must be taken seriously because of high early mortality rate.
出处
《中华内科杂志》
CAS
CSCD
北大核心
1997年第8期532-535,共4页
Chinese Journal of Internal Medicine