小儿庚型肝炎的探讨

Hepatitis G virus infection in children with hepatitis

为了探讨一种新型肝炎病毒，即庚型肝炎病毒（ｈｅｐａｔｉｔｉｓＧｖｉｒｕｓ，ＨＧＶ）在小儿中的感染特点，检测了３６例肝炎患儿及１６例健康体检儿童血清中ＨＧＶ－ＲＮＡ（套式逆转录ＰＣＲ法）。结果表明，３６例肝炎中有１１例ＨＧＶ感染者，其中６例合并慢性ＨＣＶ感染（３例接受过干扰素治疗），２例合并慢性ＨＢＶ感染，２例为慢性非Ａ－Ｅ肝炎，１例合并ＨＢＶ＋ＨＡＶ感染。１６例健康儿童均阴性。ＨＧＶ感染率在血制品输入者１０例中７例阳性，在未输入者２２例中３例阳性（两者比较，Ｐ＜０．０１），在血制品使用情况不明者２０例中１例阳性。提示输入血制品是小儿ＨＧＶ感染的主要途径，但不排除还有其他途径，感染者主要为慢性肝炎患儿。

To investigate the prevalence of hepatitis G virus (HGV) infection in children, the authors detected HGV RNA in serum from children with hepatitis and healthy children by nested reverse transcription PCR (RT PCR). The primers were derived from the NS 3/helicase region. Of 36 patients with hepatitis, 11(30.56%) were positive for HGV RNA, 16 healthy children, however, were all negative ( P <0.01); of the 11 cases with HGV infection, 6 were coinfected with HCV (3 had received alpha interferon),2 had chronic HBV infection, 1 had HBV+HAV infection and the last two had chronic non A E hepatitis. Positive results were obtained in serum from 7/10 patients who received blood product administration 13.6% who did not ( P <0.01) and 13.6% whose history of blood pro duct thransfusion was unclear. The results indicate that a major risk factor for HGV infection in children was blood product administration. HGV infection in the present series of patients was associated with chronic hepatitis.