女性偏头痛绝经后变化及防治研究

VARIATION OF FEMALE MIGRAINE AFTER MENOPAUSE AND ITS PROPHYLAXIS AND TREATMENT

对女性偏头痛绝经后仍符合诊断的３２０例患者按１１配对分析，发现绝经后附加症状增多。选取便于随访的８０例患者随机分类分成两组进行对比治疗试验，Ⅰ组每月２次服尼二雌醇２ｍｇ，日服奋乃静１２ｍｇ和日服多虑平７５ｍｇ；Ⅱ组日服邻甲氯灭酸３００ｍｇ。治疗２个月后Ⅰ组痊愈率为５７．５８％，Ⅱ组痊愈率为２７．７８％，停药后２个月Ⅰ组有２例复发。本研究提示绝经后雌激素紊乱并降低和绝经后附加症状群对偏头痛病理生理改变的重要性，并证实其相应治疗方法的合理性。

cases of female migraine after menopause according to the diagnostic criteria were stu died by using 1∶1 matched analysis. It was found that the additional symptoms increased after menopause. Eighty cases available for follow up were divided into two groups, on which the treatment tests were done. Each patient in group I took Nilestrioli 2 mg twice a month and Perphenaine 12 mg and Doxepin 75 mg per day, while each patient in group II took Tolfenamic acid 300 mg a day. Two months after treatment, the cure rates were 57.58% in group I and 27.78% in group II. Two monthes after the cessation of therapy, 2 cases had relapses in group I. These data indicate that the decrease of estrin disorder and the additional symptoms after monopause play important roles in the change of migraine physiology, and the corresponding treatment methods are rational.