NIDDM患者血浆性激素水平与心血管并发症及病程关系

RELATIONSHIP BETWEEN PLASMA SEX HORMONE AND CARDIOVASCULAR COMPLICATIONS, COURSE OF DISEASE IN NIDDM

目的了解糖尿病患者体内性激素的变化与并发症及病程之间的关系。方法用放射免疫法测定７１例ＮＩＤＤＭ患者（男性３２例，女性３９例均为绝经期）和正常对照者６２例的血浆睾酮（Ｔ）、雌二醇（Ｅ２）。将有无心血管并发症组、病程大于和小于１０年组、血糖水平高于和低于１１．１ｍｍｏ／Ｌ组进行比较。结果男性患者血浆Ｅ２、Ｅ２／Ｔ离于正常对照组，女性患者Ｅ２、Ｅ２／Ｔ低于正常对照组，差异有显著性（Ｐ＜０．０１）。男女性心血管并发症组Ｅ２、Ｅ２／Ｔ分别高于和低于无心血管并发症组。差异均有显著性。男性糖尿病患者Ｅ２、Ｅ２／Ｔ与病程呈正相关，女性患者与病程呈负相关，Ｐ均小于０．０５。Ｅ２、Ｅ２／Ｔ与血糖水平无显著性差异。结论男女糖尿病患者均有血浆性激素紊乱。Ｅ２／Ｔ升高、Ｅ２／Ｔ降低可能分别是男女糖尿病患者心血管并发症的一个易患因素。

Objective To find out the relationship between sex hormone and cardiovascular complication, as well as course of diabetes. Methods Plasma testosterone (T) and estradiol (E 2) of 71 patients ( M=32, F=39, all menopausal) with NIDDM and 62 normal controls were determined by RIA.Their results were analyzed between groups with or without complications, long or short courses of disease and high or low glucose levels respectively.Results The results showed that the plasma E 2 and E 2/T of diabetic patients in men were greatly higher than that of normal control, and those in women were greatly lower than that of normal. E 2 and E 2/T in men with cardiacand vascular complications were higher than that with no complications, and those in women were lower than that with no complications, both having significantdifferences. E 2 and E 2/T of man patients with NIDDM were correlated positively with course of disease, and that of woman patients were correlated negatively with it, both p<0.05. There was no correlations between E 2 , E 2/T and glucose level respectively. Conclusion The increasing and decreasing of E 2/T may be a risk factor of cardiac and vascular complications inmen and women patients with NIDDM respectively.