低应力对髌骨软骨软化基质蛋白多糖含量的影响

LOW STRESS AFFECT THE PROTEOGLYCAN OF CHONDROMALACIA PATELLA

目的探讨低应力对髌骨软骨软化基质蛋白多糖含量的影响。方法采用髌骨倾斜引起髌骨软骨软化的动物模型，将２４只新西兰兔定期处死后进行软骨组织病理观察、髌股关节接触压力测量、以及软骨各层蛋白多糖含量的比较。结果髌骨倾斜使髌骨内侧面软骨接触压力降低，导致内侧面髌骨软骨软化，软骨细胞变性，蛋白多糖含量减少；而髌骨外侧面软骨接触压力无明显改变，软骨变性不明显，蛋白多糖含量无明显减少。结论低应力致使软骨细胞变性，蛋白多糖合成量减少；与此同时，软骨细胞释放胶原酶等降解蛋白多糖，使软骨蛋白多糖含量进一步减少。

The aim of this paper is to study the affect of low streess at proteoglycan of chondromalacia patella.we used the twenty-four New Zealand rabbits for producing the animal model of chondromalacia patella which induced by patellar tilt.Four group of Rabbits sacrified at four different period time of postoperation.The pathohitological observation of cartilaginous tisse,contact stress measurement of patellofemoral joint,and measurement of proteoglycan of three cartilaginous layers performed.The result indicated that patellar tilt induced the degeneration of chondrocytes first,and then reduced the proteoglycan synthesis of medial cartilage side of experimental patella because of low stress of medial cartilaginous side.The remarkable changes of contact stress of patellofemoral joint,the cartilaginous degeneration,and matrix proteoglycan loss not found in the lateral cartilaginous side of patella.It is conclueded that low stess brougt about the degeneration of chondrocytes and the inhibition of proteoglycan synthesis at first,then the the chondrocytes released collagenase for degrading the mitrix proteoglycan.therefore the total quantity of proteoglycan was loss dramatically.