摘要
目的：探讨金牛腹痛片治疗胃溃疡的机制。方法：将实验动物随机分组，进行金牛腹痛片对大鼠胃液分泌的影响、对实验性胃溃疡的作用、对幽门螺杆菌（ＨＰ）的抑菌实验和安全性实验。结果：金牛腹痛片高剂量组对胃液量、１小时总酸排出量、胃蛋白酶排出量有显著抑制作用，对束缚寒冷应激性溃疡，高、低剂量组均有保护作用，对消炎痛性溃疡仅高剂量组作用明显，能显著降低毛细血管的通透性，对ＨＰ有较明显的抑制作用，临床应用亦是安全的。结论：金牛腹痛片治疗胃溃疡与其减少胃液分泌、降低胃酸和胃蛋白酶排出量、保护胃粘膜和抑制ＨＰ作用有关。
Objective:To explore the possible mechanism with regard to “jin niu fu tong” tablet in treatment of gastric ulcer.Methods:Rats were randomly divided into different groups to investigate effects of “jin niu fu tong” tablet on gastric secretion,healing of experimental ulcers,inhibition of helicobacter pylori,and safety of the drug.Results:High dose of “jin niu fu tong” tablet had a significant influence on gastric secretion,total acid output (1 hour) and gastric trypsin output.Such drug also showed a protective effect on stress ulcer induced by bound cold in both high and low dose groups.In addition,high dose of “jin niu fu tong” tablet was effective for stress ulcer caused by indomethacin.The drug significantly reduced capillary permeability,had a strong inhibition effect on helicobacter pylori,and was safe in clinical use.Conclusions:These data suggest that “jin niu fu tong” tablet may provide good therapeutic effects via reducing gastric secretion,lowering gastric acid and trypsin output,protecting gastric mucosa and inhibiting helicobacter pylori.
出处
《中国危重病急救医学》
CAS
CSCD
1997年第7期408-410,共3页
Chinese Critical Care Medicine
基金
广东省科委1995年重点科技开发项目基金
