Mueller矩阵在生物医学检测方面应用的实验研究

Experimental Study on the Technology of Biomedical Diagnosis with Optical Mueller Matrix

Mueller矩阵是公认的能很好地表述介质偏振特性的一种方法,由于散射光偏振在生物组织无创伤诊断技术等诸多领域中的重要应用价值,对组织散射特性的Mueller矩阵的研究成为国际上组织光学的热点之一。研究设计了一种新的测量Mueller矩阵的实验装置:斜入射正接收装置,并推导出一组后续数据处理的算法。由此所获得的Mueller矩阵空间分布图的清晰度不亚于其它所报道的,并且测量方法具有结构简单、方便、准确等优点。实验结果表明:入射角影响Mueller矩阵空间分布图;随着介质浓度的增大,随机介质后向散射Mueller矩阵各元素的空间分布图样减小;同时列举了真实生物组织样品(肌肉组织)的后向散射Mueller矩阵的实测结果,由此证明各向异性生物组织的后向散射Mueller矩阵各元素的空间分布图样与纤维的走向有关。

Mueller matrix is a good ways to describe the backscattered property of turbid media. It has been a hot spot in basic the study of tissue optics because of its important application to the technology of noninvasive optical diagnosis of biological tissue and other fields. In this thesis, we contrived a new experimental device which properties are oblique incidence and perpendicular detecting and a set of formularies of data processing. The results are even better than other group＇ s. It shows that our experimental device has many advantages （ simpler, more convenient and more accurate）. By the experimental device and processing method, we can draw the following conclusions： Mueller matrix is related to angle of incidence. The pattern of backscattered Mueller matrix will be downsizing as the concentration of turbid media increasing. Moreover, we also obtained the patterns of backscattered Mueller matrix of real biological tissues （muscle） , which show that the pattern is, relate to tending pattern of fiber.