纳洛酮治疗慢性Ⅱ型呼吸衰竭的临床疗效研究

Study of Clinical Efficiency of Naloxone in Treating with Chronic Type Ⅱ Respiratory Failure

目的:了解纳洛酮治疗慢性Ⅱ型呼吸衰竭的疗效。方法:将46例慢性Ⅱ型呼吸衰竭患者随机分成两组,在常规治疗基础上观察组每日一次用纳洛酮1.6mg加入5%葡萄糖盐水250ml中静滴;对照组用可拉明1.875g加入5%葡萄糖盐水250ml中缓慢静滴,疗程均为5d;观察临床症状、体征、肺功能、血气分析及副作用。结果:治疗后观察组在临床症状、体征、肺功能、血气分析等各项观察指标的改善上明显优于对照组,差异具有统计学意义(P<0.05);观察组总有效率为91.30%,对照组为65.22%,差异具有有统计学意义(P<0.05);且纳洛酮未见明显副作用。结论:纳洛酮治疗慢性Ⅱ型呼吸衰竭患者是一种安全有效的方法,值得临床推广应用。

Objective： To estimate the clinical effect of naloxone in the treatment of chronic type Ⅱ respiratory failure. Method： 46 cases of chronic type Ⅱ respiratory failure were randomly divided into two groups, namely the observation group and the controlled group. On the base of routine treatment, 1.6 mg of Naloxone and 250ml of 5% GS was used once per day in the observation group. The course of treatment was 5 days. The clinical symptom, sign, lung function, blood gas analysis and side effect were observed in the article. Result： There was significantly difference between two groups in lung function, blood gas analysis （ P 〈0.05 ）. The cure rate of observation group was significantly higher than that of control group （91.30% vs 65.22% ,P 〈0.05 ）, and naloxone had few side effects. Conclusion： Naloxone is a safe and effective drug in treating chronic type Ⅱ respiratory failure, which is worth utilizing widely in clinic.