双腔起搏患者心室起搏百分数与血浆脑钠素水平的关系

Association between cumulative percent ventricular paced and plasma brain natriuretic peptide in patients received dual-chamber pacers

目的探讨植入双腔起搏器患者术后心室累积起搏百分数与血浆脑钠素(BNP)水平的关系。方法入选107例接受DDD(R)心脏起搏器治疗的病窦综合征患者,术后随访时,通过酶联免疫吸附法检测患者血浆BNP水平,通过程控仪获取起搏器的心室累积起搏百分数,并分析两者之间的关系。结果经过中位数为60 d的随访观察,患者术后血浆BNP水平较其术前显著增高[(72.17±21.23)ng/Lvs.(52.39±18.22)ng/L,P<0.01],心室累积起搏百分数与血浆BNP水平显著正相关(r=0.578,P<0.01)。结论心室起搏可能产生起搏依赖性的心功能损害。

Objective To investigate the association between cumulative percent ventricular paced （Cum% VP） and plasma brain natriuretic peptide （BNP） level in patients received dual-chamber pacers. Methods From February 2003 to May 2006, 107 patients with sinus node dysfunction were admitted to receive dual-chamber pacers, the Cum^VP was determined from stored pacemakers data, and BNP were measured at baseline and at their first follow up visit by EIASA. Results After a median of 60 days＇ follow up, the levels of plasma BNP were significantly increased from preoperative （52.39±18.22） ng/L to postoperative （72.17±21.23） ng/L （P〈0. 01）, and the numerical coefficient of correlation Pearson r between Cum% VP and postoperative plasma BNP level was 0. 578 （P〈0.01）. Conclusions Cum%VP positively correlated with the plasma BNP level, which suggested increased cumulative ventrieularpacing may exert adverse effect on heart function.