期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

男性不育症ICSI治疗的遗传风险分析 被引量：16

Genetic Risks of Intracytoplasmic Sperm Injection for Male Infertility
下载PDF
导出
摘要 近年来,ICSI对男性不育的治疗取得了极大的成功。然而,精子的遗传学异常所带来的遗传风险引起了较大的关注。在这些不育症患者中,大部分的少弱精子症患者和部分无精子症患者选择了ICSI,所以对患少弱精子症和无精子症的男性不育夫妇进行遗传学咨询与筛查,对防止这种基因缺陷的遗传具有重要意义。本综述就不育男性的遗传学缺陷发生率进行了分析。 Recently, intracytoplasmic sperm injection （ICSI） has been extremely successful in the treatment of male infertility. How-ever, the consequent transmission of sperm cytogenetic defects and genetic defects to the offspring has aroused considerable concern. Among infertile men, those with severe spermatogenic defects, including uligozoospermia and asoospermia, are mostly the subjects for ICSI. Therefore it is very important to obtain cytogenetic and chromosomal information on these infertile patients and prevent the inheritance of these genetic defects. This review offers an analysis on the genetic defects among infertile men.
作者 邵法明 朱晓斌 李铮
机构地区 宁波大学医学院附属医院泌尿外科 上海交通大学附属仁济医院泌尿外科
出处 《中华男科学杂志》 CAS CSCD 2008年第1期71-74,共4页 National Journal of Andrology
关键词 男性不育 遗传风险 卵细胞胞质内单精子注射 基因缺陷 male infertility genetic risk intracytoplasmic sperm injection genetic defect
分类号 R698.2 [医药卫生—泌尿科学]
  • 相关文献

参考文献22

  • 1Toumaye H. ICSI: a technique too far [ J ] ? Int J Androl, 2003, 26(2) : 63-69.
  • 2Peterlin B, Kunej T, Sinkovec J, et al. Screening for Y chromosome microdeletions in 226 Slovenian subfertile men [ J ]. Hum Reprod, 2002, 17(1) :17-24.
  • 3Dohle GR, Halley D J, van Hemel JO, et al. Genetic risk factors in infertile men with severe oligozoospermia and azoospennia[ J ]. Hum Reprod,2002,17 ( 1 ) . 13-16.
  • 4朱晓斌,郭安亮,曹小蓉,刘勇,孙序序,姚见儿,王毅,王益鑫,李铮.改良多重聚合酶链反应检测Y染色体AZF微缺失[J].中华男科学杂志,2006,12(3):199-201. 被引量：25
  • 5Thangaraj K, Gupta NJ, Pavani K, et al.Y chromosome deletions in azoospermic men in India [J]. J Androl, 2003, 24(4) : 588-597.
  • 6Cram DS, Ma K, Bhasin S, et al. Y chromosome analysis of infertile men and their sons conceived through intracytoplasmic sperm injection: vertical transmission of deletions and rarity of de novo deletions [J]. Fertil Steril, 2000, 74(5) :909-915.
  • 7Oates RD, Silber S, Brown LG, et al. Clinical characterization of 42 oligospermic or azoospermic men with micredeletion of the AZFc region of the Y chromosome, and of 18 children conceived via ICSI [ J]. Hum Repred, 2002,17( 11 ) :2813-2824.
  • 8Tomita Y, Bilim V, Kawasaki T, et al. Frequent expression of Bcl-2 in renal-cell carcinomas carrying wild-type p53 [ J ]. Int J Cancer, 1996, 66(3) : 322-325.
  • 9Liu J, Lissens W, Silber SJ, et al. Birth after preimplantation diagnosls of the cystic fibrosis delta F508 mutation by polymerase chain reaction in human embryos resulting from intracytoplasmic sperm injection with epididymal sperm [ J]. JAMA, 1994,272 (23) :1858-1860.
  • 10邱毅,王磊光,杨丹彤,王苏梅.78例先天性双侧输精管缺如不育患者诊断及遗传学分析[J].中国优生与遗传杂志,2006,14(2):73-76. 被引量：5

二级参考文献16

  • 1邱毅,杨丹彤,王苏梅,施红,高建文,王志新.输精管可复性栓堵术后精浆肉毒碱含量的改变[J].生殖与避孕,1995,15(4):272-275. 被引量：8
  • 2Kuroda-Kawaguchi T, Skaletsky H, Brown LG, et al. The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men [ J ]. Nat Genet, 2001,29(3) :279-286.
  • 3Simoni M, Bakker E, Krausz C. EAA/EMQN best practice guidelines for molecular diagnosis of Y-chromosomal microdeletions.State of the art 2004[J]. Int J Androl, 2004,27(4) :240-249.
  • 4Ali S, Hasnain SE. Genomics of the human Y-chromosome. 1.Association with male infertility[J]. Gene, 2003, 321:25-37.
  • 5Repping S, Skaletsky H, Brown L, et al. Polymorphism for a 1.6 Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection [ J ].Nat Genet, 2003, 35 ( 3 ) :247 -251.
  • 6Machev N, Saut N, Longepied G, et al. Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility [ J ]. J Med Genet, 2004, 41 ( 11 ) :814-825.
  • 7Dada R,Gupta NP,Kucheria K.Molecular screening for Yq microdeletion in men with idiopathic oligozoospermia and azoospermia[J].J Biosci,2003,28:163-168.
  • 8Tiepolo L,Zuffardi O.Location of factors controlling soermatogenesis in the nonfluorescent portion of the human Y chromosome long arm[J].Hum Genet,1976,34:119-124.
  • 9Reigo R,Alagappa RK,et al.Severe oligozoospermia resulting from deletions of azoospermia factor gene on Y chromosome[J].Lancet,1996,347:1290-1293.
  • 10Nakahori Y,Kobayashi K,et al.A locus of the candidate gene family for azoospermia factor (YRRM2) is polymorphic with a null allele in Japanese males[J].Hum Mol Genet,1994,3(9):1709-1715.

共引文献29

同被引文献153

引证文献16

二级引证文献95

中华男科学杂志
2008年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部