慢性重型乙型肝炎人工肝血浆置换疗法的临床研究

Clinical study of treatment with artificial liver support system-plaxma exchange in the patients of severe hapatitis

目的观察慢性重型乙型肝炎人工肝支持系统（artificial liver support system，ALSS）-血浆置换（plasma exchange，PE）治疗前后临床症状、肝功能、凝血功能及IL-10的变化。方法将151例慢性重型乙型肝炎患者分成治疗组和对照组，治疗组在综合药物治疗的基础上加用ALSS-PE，而对照组仅采用药物治疗。治疗前后常规观察两组患者临床症状、肝功能、凝血酶原时间（PT）、凝血酶原活动度（PTA）及用ELISA法检测IL-10的变化。结果治疗组在临床症状、肝功能、PT、PTA等指标的改善上明显优于对照组（P〈0．05）；IL-10有上升趋势（P〈0．05）。结论ALSS-PE能明显提高药物治疗慢性重型乙型肝炎的疗效，升高IL-10，减轻肝脏炎症反应。

Objective To observe the effect of artificial liver support system（ALSS）-plasma exchange （PE）on clinical symptoms, liver function, blood clotting function and the concentrations of IL-10 in patients with severe hepatitis. Method 151 cases with chronic severe hepatitis B were divided into treatment group and control group. Treatment group received ALSS-PE with drugs, control group only received kinds of regular drugs. Clinical symptoms, liver function, blood clotting function of the two groups were observed, and the concentrations of IL-10 were detected by ELISA. Results The result showed that the effect of treatment group in clinical symptoms, liver function, blood clotting function was obviously better than that of control group, the concentrations of IL-10 in treatment group increased. Conclusions M.SS-PE can significantly increase the therapeutic effect of drugs, increase the concentrations of IL-10, and reduce in-flammatory reaction of liver.