铁离子对环吡酮胺抑制犬小孢子菌的影响

Mechanism of interferance of iron ion with Ciclopirox olamine

目的:探索抗真菌药物环吡酮胺可能的作用机制。方法:利用微量液基稀释法和纸片扩散法,测定抗真菌药物环吡酮胺抑制犬小孢子菌时铁离子的作用。结果:所有受试菌株均表现为对环吡酮胺耐药。结论:铁离子参与了抗真菌药物环吡酮胺对犬小孢子菌的抑菌作用。

Objective：To explore the mechanism of interferance of iron ion with the antifungal drug-Ciclopirox olamine. Methods：To utilize micro broth dilution method and disk diffusion method to determine whether the iron levels is critical factor for the antifungal action of Ciclopirox against Microsporum canis.Results：Iron ion depressed the antifuagal action of Ciclopirox against Microsporum cani.Conclusion：Iron ion can join in the antifungal action of Ciclopirox against Microsporum cani.