盐酸伐昔洛韦治疗儿童疱疹性咽峡炎的临床观察

Clinic observation of valaciclovir hydrochloride in the treatment of children herpangina

目的:探讨用盐酸伐昔洛韦治疗儿童疱疹性咽峡炎的疗效及其安全性。方法:对54例门诊疱疹性咽峡炎患儿采用随机分组的方法设立治疗组和对照组,治疗组26例给予盐酸伐昔洛韦10mg·kg-·1d-1,po,bid;对照组28例用利巴韦林10mg·kg-1·d-1～15mg·kg-1·d-1加入生理盐水静滴,qd。结果:从开始用药至痊愈时间,治疗组平均为(4.0±1.2)d,对照组平均为(6.5±1.5)d,两组差异有显著性(P<0.05)。两组在治疗过程中无其他明显不良反应。结论:盐酸伐昔洛韦治疗儿童疱疹性咽峡炎疗效明显,依从性好,安全性较高,值得临床推广应用。

Objective：To estimate the therapeutic effect and safety of valaciclovir hydrochlofide in the treatment of children herpangina.Methods：54 children with herpangina were divided into two groups at random, in one group （experimental group） 26 patients were treated with valaciclovir hydrochloride in dose of 10mg·kg^-1·d^-1, po, bid; another group （control group） consisting of 28 cases, which were therapied of ribovirin, the dose was 10mg·kg^-1·d^-1--15mg·kg^-1·d^-1 with intervenous drop infusion, qd.Results：Time of healing between two groups was obviously different, the experimental group was about in 4 days （4.0±1.2） and the other group was about six and a half days.Conclusion：Therapeutic effect of valaciclovir hydrochloride in children herpangina was obvious and compliance and safety are also fine, it can be used widely in clinic.