抗菌药继发真菌感染31例病例报告分析

Analysis of 31 cases of fungal infections following antibiotics therapy

目的:调查抗菌药物继发真菌感染的现状,促进抗菌药的合理应用。方法:利用中国生物医学文献光盘数据库检索,获得1995年1月～2004年12月间关于抗菌药继发真菌感染的病例报告27篇并进行回顾性调查分析。结果:抗菌药继发真菌感染患者未集中于某一特定年龄段;基础疾病多发于呼吸系统和消化系统,分别占继发感染总例次的39.68%和30.16%;继发真菌感染前应用的抗菌药以青霉素类和头孢类为主,各占感染总例次的21.88%;白色念珠菌检出例次居首位,为41.46%;呼吸道是感染发生最多的部位,占39.02%。结论:应用抗菌药应有恰当的用药指征,抗菌药的选择应以药敏试验为依据,避免多种抗菌药长期使用。

Objective：To assess the clinical feature of fungal infections due to antibiotics, and improve the rational administration of antibiotics.Methods：The data from 31 individual patients published in 27 different reports collected from CBMdisc （January 1995 to December 2004） after a comprehensive search was studied retrospectively.Results：The patients were not concentrated in one age bracket; the underlying diseases located mainly in respiratory system （39.68%） and digestion system （30.16%）; the fungal infec- tions were mostly associated with the use of potent and broad spectrum antibiotics such as penicillins （21.88%） and cephalosporin （21.88%）; the main germ of fungal infection was Candida albicans accounting for 41.46%; the infection sites lay mostly in respiratory system, accounting for 39.02%.Conclusion：The clinical selecting of antibiotics should be based on the bacterial culture and drug susceptibility test, the combined use of antibiotics should be reduced, and the administration of antibiotics for a long time should be avoided.