络活喜治疗慢性肾功能不全31例临床观察

Clinical Observation of the Effect of Amlodipine on Chronic Renal Insufficiency in 31 Cases

用氨氯地平（络活喜）（ＡｍｏｌｏｄｉｐｉｎｅＮｏｒｖａｓｃ）对３１例慢性肾功能不全伴高血压患者进行为期３个月的临床观察，治疗后血尿素氮（ＢＵＮ）、血肌酐（Ｓｃｒ）水平明显下降（１６．１±５．３ｖｓ１３．２±６．２ｍｍｏｌ／Ｌ，Ｐ＜０．０５；２５８±６２ｖｓ２２１±８２ｍｍｏｌ／Ｌ，Ｐ＜０．０５）；收缩压和舒张压明显减低（２２．６±０．９ｖｓ９．３±１．６ｋＰａ，Ｐ＜０．０１；１２．７±０．５ｖｓ１０．６±０．８ｋＰａ，Ｐ＜０．０１），同时对尿蛋白有降低作用（１．４２±０．５ｖｓ１．２３±０．６ｇ／２４ｈ，Ｐ＞０．０５），副作用轻微。认为络活喜可作为治疗慢性肾功能不全伴高血压病人的有效药物之一。

Therapeutie effectiveness of amoldipine in 31 patients with chronic renal insufficiency and renal hypertension was observed for three months.After the treatment mentioned above levels of blood urea nitrogen(BUN)and serun creatinine(Scr)markedly decreased(16 1±5 3 vs 13 2±6 2mmol/L,P<0 05;258±62 vs 221±82mmol/L,P>0 05);and the systolic and diastolic blood presure markedly lowered(22 6±0 9 vs 9 3±1 9kPa,P<0 01;12 7±0 5 vs 10 6±0 8kPa,P<0 01)。At the same time,the drug had the effect of eliminating urinary protein(1 4±0 5 vs 1 23±0 6g/24h,P>0 05).The side effects of the drug were slight.It was considered that the drug was one of the effective drugs in treating patients with chronic renal insufficiency and renal hypertension.