米力农的差示扫描量热分析与热重分析

Thermoanalysis of milrinone by DSC and TGA

目的:研究心血管药物米力农晶体的吸附水、结晶水、熔点、晶型变化等理化性质。方法:用差示扫描量热分析(DSC)和热重分析(TGA)法研究其热变化,采用X-射线粉末衍射实验研究其晶型变化。结果与结论:米力农样品不含结晶水。试样从201.04℃开始失重,脱去吡啶环,并有对应的吸热峰产生;在293.06℃发生微小吸热反应,可能是样品中的少量亚稳态晶体组分发生熔化反应,或是发生了微小的晶型转变;最后,到达314.66℃(熔点)开始熔化,随即样品发生完全分解反应。

Objective： To characterize the physicochemical properties of cardio cerebrovascular drug milrinone include its contents of absorbed water and water of crystallization, melting phase, and crystallization changes. Methods： Differential scanning calorimetry （DSC） and thermogravimetric analysis （TGA） techniques were conducted to determine the thermal characteristics, and X-ray diffraction analysis was also used to determine its crystal type. Results and Conclusion： The sample didn＇t contain any crystallization water. Milrinone began to fall apart at 201.04℃ with the naphthyridine component decomposed and initiated an minor endothermic reaction at 293.06℃, which may be due to a delicate melting reaction or a tiny crystal transition had occurred from certain tiny metastable component ; it started melting at 314. 66℃, then decomposed completely.