摘要
目的:使用喷雾干燥方法得到噻托溴铵的超细粉末。方法:采用单因素试验和正交试验筛选出合适的喷雾干燥条件。结果:料液浓度为8.0%的乳糖水溶液(其中含0.1%的噻托溴铵),加入占乳糖重量8.0%的L-亮氨酸;进风温度145℃;进料速度3.5 mL.min-1;换风程度100%。结论:该方法简便实用,得到噻托溴铵的超细粉末,粒径均小于5μm。
Objective ：To obtain totropium bromide ultrafine powders by spray drying. Methods： The single factor and orthogonal experiments were designed to screen out suitable operation conditions of spray drying. Results： The optimal spray drying conditions were as follows： 8.0% lactose water solvent was used as main excipient （ containing 0. 1% totropium bromide and 8.0% L-leucine） ; wind temperature was 145℃ ; material feeding speed was 3.5 mL·min^-1 , wind rowing speed was 100%. Conclustions： The method is useful and convenient, obtained particle diameter of totropium bromide uhrafine powders is less than 5 μm.
出处
《药学与临床研究》
2008年第1期26-28,共3页
Pharmaceutical and Clinical Research
关键词
噻托溴铵
超细粉末
喷雾干燥
Totropium bromide
uhrafine powders
spray drying
