期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

着丝粒生物学

Centromere Biology
下载PDF
导出
摘要 着丝粒的关键作用是保证细胞减数分裂和有丝分裂的顺利进行,保证生物的遗传.近年来随着对多个物种的着丝粒测序之后对着丝粒的功能提出了很多相互矛盾的假说.本文阐述了低等真核生物的着丝粒没有重复序列而高等真核生物的着丝粒具有大量的重复序列,并且简述了各物种着丝粒的组成和各类与组蛋白H3、核仁、着丝粒DNA序列及DNA的高级结构相关的着丝粒功能模型. The significant role of centromere is to perpetuate the process of mitosis and meiosis and maintain inheritance of organism. After centromeres in diverged species were sequenced in recent years, many competing models towards the explanation of centromere formation and function were raised. In this review, there is no repetitive sited in the region of functional centromere whereas there are an amount of repetitive sequences existed in that region. This review dictates the composition of centromeres in diverged organisms and various models related to the histone H3, nucleosome, ,centromeric DNA and the higher structure of the DNAs.
作者 郭文久
机构地区 安康学院化学与生命科学系
出处 《安康学院学报》 2008年第1期81-85,共5页 Journal of Ankang University
关键词 着丝粒 重复序列 组蛋白 α-卫星DNA centromere repetitive sequence histone α - satellite DNA
分类号 Q751 [生物学—分子生物学]
  • 相关文献

参考文献42

  • 1[1]BARRY A.E.,HOWMAN,E.V.,CANCILLA,M.R.et al.Sequence analysis of an 80 kb human neocentromere[J].Hum Mol Genet 1999,8 (2):217 -27.
  • 2[2]BAUM M.,NGAN,V.K.and CLARKE,L The contromeric K-type repeat and the central core are together sufficient to establish a functional Schizosaccharomyces pombo centromere[J].Mol Biol Cell 1994,5 (7):747-61.
  • 3[3]BLOWER M.D.SULLIVAN,B.A.and KARPEN,G.H.Conserved organization of centromeric chromatin in flies and humans[J].Dev Cell 2002,2 (3):319 -30.
  • 4[4]CLARKE L Contromeres:proteins,protein complexes,and repeated domains at centromeres of simple eukaryotes[J].Curr Opin Genet Dev 1998,8 (2):212-8.
  • 5[5]CLARKE L.and CARBON,J.Isolation of a yeast centromere and construction of functional small circular chromosomes[J].Nature 1980,287 (5782):504-9.
  • 6[6]COPENHAVER G.P.NICKEL,K.KUROMORI,T.et al.Genetic definition and sequence analysis of Arabidopsis centromeres[J].Science.1999,286 (5449):2468 -74.
  • 7[7]COPENHAVER G.P.and PREUSS,D.Gentromeres in the genomic era:unraveling paradoxes[J].Curr Opin Plant Biol.1999,2 (2):104 -8.
  • 8[8]COTTAREL G.SHERO,J.H.HIETER,P.et al.A 125-base-pair CEN6 DNA fragment is sufficient for complete meiotic and mitotic centromere functions in Saccharomyces cerevisiae[J].Mol Cell Biol 1989,9 (8):3342-9.
  • 9[9]EICHLER E.E.Repetitive conundnuns of centromere structure and function[J].Hum Mol Genet 1999,8(2):151 -5.
  • 10[10]GRADY D.L.RATLIFF,R.L ROBINSON,D.L.et al.Highly conserved repetitive DNA sequences are present at human centromeres[J].Proc Natl Acad Sci U S A 1992,89 (5):1695 -9.
安康学院学报
2008年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部