氯化钴积聚缺氧诱导因子对5／6肾切除大鼠肾小管间质纤维化的影响
被引量：1
摘要
进展性肾脏疾病存在慢性缺氧和。肾小管周嗣毛细血管（PTC）的丧失，缺氧诱导因子（HIF）是缺氧适应时恢复细胞内环境稳定的一个核心调节因子，其转录激活靶基因后具有刺激血管新生、红细胞生成和无氧代谢等诸多作用。已有研究证实，通过氯化钴（CoCl2）积聚HIF可改善大鼠的急性缺血性肾损害。本实验采用大鼠5／6肾切除的慢性肾功能衰竭模型，观察CoCl2对残肾HIF积聚和残肾功能的影响，并初步探讨其机制。
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2008年第1期56-57,共2页
Chinese Journal of Nephrology
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