综合抗凝溶栓治疗对左心房、机械瓣血栓的疗效

Effect of combine anticoagulation and thrombolysis on throm in left atrium and machine valva

目的:探讨华法令、低分子肝素钙、硫酸氯吡格雷和尿激酶联合治疗人工瓣膜置换术后血栓形成的疗效及安全性。方法:32例人工瓣膜置换术后血栓形成患者应用华法令、低分子肝素钙、硫酸氯吡格雷(机械瓣加用尿激酶)联合治疗,观察血压,心功能,凝血指标,血、尿常规及副作用。结果:经治疗8～20d后血栓消失21例(65.6%),明显缩小10例(31.3%),出现少量出血7例(21.9%),经及时处理后缓解,无严重出血。结论:华法令、低分子肝素钙、硫酸氯吡格雷和尿激酶联合治疗人工瓣膜置换术后血栓安全有效。

Objective： To study the effect of combine treatment with warfarin, low molecular weight heparin, clopidogrel and urokinase on throm in left atrium and machine valva. Methods： The 32 patients with throm in left atrium and machine valva were treated with warfarin, low molecular weight heparin, clopidogrel and urokinase. The therapeutic effect and safety were observed in these patients. Results： After treat 8-20 d the throm disappeared in 21 patients （65.6%）, and significantly decreased in 10 patients （31.3%） ; there were small amounts bleeding in 7 patients （21.9%）, but no severity bleeding. Conclusion： Combine treatment with warfarin, low molecular weight heparin, clopidogrel and urokinase is an effective and safely treatment method.