血清resistin与单纯肥胖或代谢综合征的关系

The relationship between serum resistin and isolated-obesity or metabolic syndrome

目的研究单纯肥胖或代谢综合征（metabolic syndrome，MS）患者血清抵抗素（resistin）的水平与健康对照者比较是否有差别，从而确定血清resistin与单纯肥胖或代谢综合征是否相关。方法健康对照者54例，单纯肥胖60例，均为2005—2006年在我院进行体检的志愿者；代谢综合征患者58例，为2005～2006年在我院就诊的符合IDF关于代谢综合征诊断标准的患者，由专人记录并测定受试者的年龄、性别、身高、体重、腰围、臀围及血压等临床资料。采集受试者外周静脉血，测定空腹血糖、血脂、resisfin、胰岛素原（PI）、真胰岛素（TI）、胰高血糖素，并计算BMI、WHR、BF、PI／TI、HOMA．IR指数。结果正常人、单纯肥胖、代谢综合征患者血清中resistin的水平无统计学差异。结论血清resistin水平可能不是联系肥胖、胰岛素抵抗及代谢综合征的主要纽带。

Objective To research the relationship between serum resistin and isolated-obesity or metabolic syndrome （MS）.Methods Fifty-four healthy subjects and sixty patients with isolated-obesity came from volunteers who accepted health examination from 2005 to 2006 in our hospital. According to IDF standards, fiftyeight MS in our hospital during 2005 - 2006 took part in our study. Clinical information was recorded by special person. Fasting glucose, lipid, resistin, PI, TI, glueagon were measured and BMI, WHR, BF, PI/TI, HOMA-IR were tested. Results No significant difference was found among healthy persons and patients with isolatedobesity or MS.Conclusion Serum level of resistin may not be related to obesity,insulin-resistance or MS.