对甲苯磺酸催化微波合成乙酰水杨酸的研究

Study on the microwave synthesis of acetylsalicylic acid by p-Toluene Sulphonic Acid catalyst

以水杨酸和乙酸酐为原料,以对甲苯磺酸为催化剂,微波辐射合成了乙酰水杨酸,并考察了影响反应的因素。实验表明:在n(水杨酸):n(乙酸酐)=1∶1.7,催化剂用量为水杨酸质量的2.5%,微波输出功率为151W,辐射时间为60s,产率可达91.2%。

The synthesis of acetyl salicylic acid from salicylic acid and acetic anhydride was studied with microwave radiation and p-toluene sulphonic acid as catalyst. The influential factors on the reaction were investigated. The experimental results showed that appropriate conditions were： molar ratio of salicylic acid to acetic anhydride was 1：1.7, weight of catalyst was 2.5% of the salicylic acid, microwave power was 151 W, the time of radiation was 60 s. The yield was about 91.2%.