老年人群代谢综合征与十年心脑血管疾病死亡率关系的研究

Association between metabolic syndrome and the 10 years mortality of cerebro-cardiovascular diseases in the senile population

目的了解我国老年人群中代谢综合征（MS）的患病率以及其与心脑血管疾病死亡率的关系。方法选取1996—1997年于我院进行健康体检的年龄在60岁以上的老年人1926例，共随访10年。MS采取2004年中华医学会糖尿病学分会推荐的标准进行诊断。按照是否诊断为MS分为非MS组（组1）和MS组（组2）。Cox比例风险模型用于心脑血管疾病生存分析以及组别之间发生心脑血管疾病死亡的相对危险度（RR）的比较。结果人群中基线水平时符合MS诊断标准的人数为482人，占总人数25、03％。组1的心脑血管疾病死亡率为2．55／1000人年，组2为6．82／1000人年。累积生存率组1为97．14％，组2为92．46％。与组1相比，组2发生心脑血管疾病死亡的RR2．52（95％CI 1．367．4．661，P〈0．05）。结论老年人群属于MS高发与高危人群，MS与心脑血管死亡关系密切，MS人群具有更高的心脑血管死亡率及死亡风险。

Objective To assess the prevalence of metabolic syndrome （MS） and its association with mortality of cerebro-cardiovascular diseases in senile population. Methods Data were collected from 1926 people aged 60 and over, who took part in routine health examination in our hospital from 1996 to 1997. All subjects were followed up for 10 years. MS was diagnosed by using the definition recommended by Chinese Diabetic Society in 2004. Cox-proportional hazards models were used in survival analyses and to calculate the relative risk （RR） of cerebro-cardiovascular diseases mortality. Results The prevalence of MS was 25.03% （n = 482, Group 2） in this population. The 10 year mortality of eerebro-eardiovaseular diseases was significantly higher （6. 82/1000-person year vs. 2.55/1000-person year, P 〈 0. 05） and the cumulative survival rate was significantly lower （92.46%vs. 97. 14% , P 〈0. 05） in group 2 compared that in group 1 （ non-MS, n = 1444）. Compared with group 1, RR of eerebro-eardiovaseular diseases mortality was 2. 52（95% CI 1. 367 -4. 661 ,P 〈0. 05）in group 2. Conclusion There was a high prevalence of MS in the senile population and MS was associated with higher 10 years mortality of eerebro-eardiovaseular diseases.