如何正确理解抗真菌药物体外敏感试验结果对临床用药的指导价值

How to interpret the guidance value of in vitro susceptibility test of anti-fungal drugs on dinical practice

随着临床侵袭性真菌感染患者的增加，真菌疾病的诊断和治疗倍受关注，临床亟须实验室在真菌鉴定和药敏方面提供帮助。本文将围绕临床和实验室共同关心的几个问题展开阐述，包括抗真菌药物体外药敏的发展历史和方法学进展，酵母菌和丝状真菌体外药敏的判读，折点解释以及对于临床的指导意义。本文同时紧密结合临床常用的几种抗真菌药物，以期从操作层面帮助实验室提高真菌药敏的工作水平，帮助临床更好地理解各种抗真菌药物的体外药敏结果。

The diagnosis and treatment of invasive fungal infections has been attracting more and more attention along with the increase incidence in the current clinical practice. We hereby work out this paper to elaborate some key issues, covering the history and methodology of anti-fungal susceptibility testing, the MIC recognition of yeast fungus and mycelial fungus, breakpoint interpretation, and finally the guidance for clinical practice. To better understand susceptibility test results and improve the guality of susceptibility tests in this review,we chosed several most-often used anti-fungal drugs and explained their effect activity.