干预策略对临床细菌耐药率的影响

The influence of interventin strategy on bacterium drug risistance in clinic

目的:研究通过干预策略限制抗菌药物的使用率和控制耐药质粒在院内传播后而对抗菌药物敏感性的影响。方法:2006年本院制定了抗菌治疗指南,采取一系列措施控制抗菌药物的使用,纠正不合理用药。结果:2006年大部分抗菌药物的敏感性显著高于2005年。但头孢哌酮/舒巴坦和环丙沙星2006年的敏感性低于2005年。结论:采取综合措施限制抗菌药物的使用率和控制耐药质粒在院内传播能恢复抗菌药物的敏感性,降低细菌耐药率。

OBJECTIVE To study the influence of limiting the use of antibacterials and controlling the distribution of resistance plasmid by intervertion strategy on the sensitivity of the drugs. METHODS A hospital guideline of antibacterial treatment was adopted in 2006 to control the usage of antibacterials, irrational use of antibacterials was rectified. RESULTS In 2006 the sensitivity of majority of antibiotics was obviously higher than in 2005, but the sensitivity of Sulbactam,Cefopcrazone and Ciprofloxacin was lower in 2006 than in 2005. CONCLUSION The bacterial drug resistance could be reduced by limiting the usage of antifaterials and controlling the distribution of drug resitance plasmid.