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Spot14基因研究进展 被引量：12

Research progress of Spot14 gene
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摘要 甲状腺激素响应Spot14蛋白(THRSP)是一种分子量较小的酸性蛋白,该蛋白能够对甲状腺激素迅速响应。Spot14基因在脂肪生成调控中起重要作用,是参与控制脂肪生成酶活性的转录因子。文章对该基因的结构、表达及其功能等方面的研究进展进行了综述。 Thyroid hormone responsive Spot14 （THRSP） is a small acidic protein that can respond to thyroid hormone rapidly. Spotl4 gene has been postulated to play a role in lipogenesis, which implicated as a transcription factor involved in control of lipogenic enzymes. This review summarized some recent progresses in the study of Spotl4 gene structure, expression and function.
作者 曹志平 李辉
机构地区 东北农业大学动物科学技术学院
出处 《东北农业大学学报》 CAS CSCD 2008年第2期285-288,共4页 Journal of Northeast Agricultural University
基金 国家自然科学基金重点项目(30430510) 教育部新世纪优秀人才支持计划项目(NCET-04-0343)
关键词 Spot14基因 结构 表达 功能 8pot14 gene structure expression function
分类号 Q753 [生物学—分子生物学]
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参考文献19

  • 1Wang X, Carre W. Zhou H. et al. Duplicated Spot 14 genes in the chicken: characterization and identification of polymorphisms associated with abdominal fat traits[J]. Gene, 2004, 332: 79-88.
  • 2Cunningham B A, Maloney M, Kinlaw W B. Spot 14 protein-pr- otein interactions: evidence for both homo-and heterodimer formation in vivo[J]. Endocrinology, 1997, 138: 5184-5188.
  • 3Chert S E, Long D W, Nestor K E, et al. Effect of divergent selection for total plasma phosphorus on plasma and yolk very low density lipoproteins and plasma coneentrations of selected hormones in laying Japanese quail[J]. Poult Sci, 1999, 78(9): 1241- 1251.
  • 4Horvat S, Bunger L, Falconer V M, et al. Mapping of obesity QTLs in a cross between mouse lines divergently selected on fat content [J]. Mamm Genome, 2000, 11: 2-7.
  • 5Liu H C, Towle H C. Functional synergism between multiple thyroid hormone response elements regulates hepatic expression of the rat S14 gene[J]. Mol Endocrinol, 1994(8): 1021-1037.
  • 6Koo S H, Towle H C. Glucose regulation of mouse S(14) gene expression in hepatocytes[J]. Biol Chem, 2000, 275(7): 5200-5207.
  • 7Martel P M, Bingham C M, McGraw C J, et al. S14 protein in breast cancer cells: direct evidence of regulation by SREBP-Ic, superinduction with progestin, and effects on cell growth[J]. Exp Cell Res, 2006, 312(3): 278-288.
  • 8Campbell M C, Anderson G W, Mariash C N, Human spot14 glucose and thyroid hormone response: characterization and thyroid hormone response element identification [J]. Endocrinology, 2003, 144(12): 5242-5248.
  • 9Compe E, de Sousa G, Francois K, et al. Spot 14 protein interacts and cooperates with chicken ovalbumin upstream promoter transcription factor 1 in the transcription of the L-type pyruvate kinase gene through a specificity protein 1 (Spl) binding site[J]. Biochem J, 2001, 358: 175-183.
  • 10Wang X, Carre W, Rejto L, et al. Global gene expression profiling in liver of thyroid manipulated and or growth hormone injected broiler chickens[J]. Poult Sci, 2002, 81(Suppl. 1): 63.

同被引文献165

引证文献12

二级引证文献26

东北农业大学学报
2008年 第2期

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