加替沙星对呼吸道细菌性感染的临床研究

Clinical Randomized Controlled Trials of Gatifloxacin Injection in Treatment of Bacterial Infections of Respiratory Tract

目的观察国产加替沙星注射液治疗呼吸道感染的临床疗效与安全性。方法64例病人（其中急性化脓性扁桃体炎16例，急性支气管炎27例，社区获得性肺炎20例，支气管扩张1例）随机分为治疗组与对照组。治疗组32例，用加替沙星注射液400叫次，静点；对照组32例，用左氧氟沙星注射液200吲次，静点2次／d；疗程均为7～14d。结果治疗组和对照组有效率分别为97％和94％，P〉0．05。细菌清除率分别为96％和92％，P〉0．05。不良反应发生率分别为10％和13％，P〉0、05。结论加替沙星注射液治疗呼吸道细菌性感染疗效好、使用安全、方便。与左氧氟沙星疗效相仿。

Objective To evaluate the efficacy and safety of domestic gadfloxacin injection in the treatment of respiratory tract bacterial infections.Methods A total of 64 patients（16 with acute purulent tomillitis,27 With acute bronchitis,20 with community acquired pneumonia and 1 with bronchiectasis） were randomly divided into treatment group and control group.Thirty- two patients of the treatment group were treated with gatifloxacin injection 400 rng, iv, gtt,qd for 7～ 14 d.Thirty- two patients of the control group were treated with levofloxacin injection 200 rng, iv, gtt, bid for 7～ 14 d.Results The total clinical effective rate was 97% in treatment group and 94% in control group.There was no significant difference（ P 〉 0.05）between two group in the clinical efficacy.There was also no significant difference（96% to 92%, P 〉 0.05）between gatifloxaein group and levofloxacin group in the bacterial clearance rate.The incidence rate of adverse reactions was 10% in the treatment group and 13% in the control group（ P 〉 0.05） .No severe adverse reactions were found. Conclusion Gatifloxacin injection is an effective and safe antibiotics for the treatment of respiratory tract bacterial infections.