摘要
目的观察替米沙坦治疗前后慢性充血性心衰患者心功能的变化,研究替米沙坦对心室重构的影响。方法52例慢性心衰患者在应用利尿剂、受体阻断剂、洋地黄治疗的基础上随机分为A组(n=24)和B组(n=28),A组给予替米沙坦40mg/d;B组给予贝那普利10mg/d口服。治疗前及治疗后6个月分别检查超声心动图测定心功能和心室重构指标。结果两组在治疗后6个月,NYHA分级较治疗前均有改善,差异有显著性(P<0.05);两治疗组间差异无显著性(P>0.05)。两组在治疗后6个月左室射血分数、左室收缩末内径、左室舒张末内径较治疗前均有改善,差异有显著性(P<0.05);两治疗组间差异无显著性(P>0.05)。结论替米沙坦和贝那普利具有相似的抗心室重构效应,替米沙坦的耐受性更好。
Objective To evaluate the effects of telmisartan on patients with chronic congestive heart failure （CHF）. Fifty- two patients were randomly divided into group A consisted of 24 patients treated with telmisartan（40mg, po, qd） for 6 months and group B consisted of 28 patients given benasepril （ 10mg, po, qd） for 6 months. The changes of NYHA class, biochemistry, liver function, renel function and echecardiography were observed. Comparison of thickness of ventricle byultrasound was made before and after treatment. Results After 6 months of therapy, NYHA class, left ventricular end diastolic diameter （LVDD）, left ventricular end systolic diameter （LVSD）, and left ventricular ejection fraction （LVEF） of both groups were improved significantly （P 〈 0.05）, without significant difference（P〉O,d5） betwecntwogroups. Conclusion Telmisartan is similar with benasepril in treatment of CHF, which is able to remodel the hypertrophied ventricle, and ameliorates the heart function.
出处
《中国热带医学》
CAS
2008年第1期38-39,共2页
China Tropical Medicine
