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AIF诱导细胞凋亡 被引量：6

AIF in Apoptosis Induction
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摘要 凋亡诱导因子(apoptosis-inducing factor,AIF)是存在于线粒体膜间隙中的黄素蛋白,它不仅具有氧化还原和电子传递功能,还具有促细胞凋亡功能,从而在维持细胞正常生理活动中具有重要作用。在外界死亡触发信号刺激下,AIF可转移到细胞核,引起不依赖经典Caspase途径的细胞凋亡,其以染色质凝集和DNA大片段断裂为特征。P53、Bcl-2、热休克蛋白-70、钙调蛋白参与了AIF诱导凋亡的发生。 AIF plays a key role in maintaining the life-supporting cell activity since it has the functions of oxideo-reductases and electron transfers. If it is stimulated by the external death-triggering signals, it will translocate to nucleus from mitochondria, which can induce independent caspase apoptosis, characterized by chromatin condensation and breakage of large DNA segments. P53, Bcl-2, HSP-70 and CaM take part in the AIF-induced apoptosis.
作者 张军 胡大海
机构地区 第四军医大学西京医院烧伤与皮肤外科
出处 《医学分子生物学杂志》 CAS CSCD 2008年第1期87-90,共4页 Journal of Medical Molecular Biology
关键词 凋亡诱导因子 细胞凋亡 线粒体 AIF apoptosis mitochondria
分类号 R285.5 [医药卫生—中药学] R735.7 [医药卫生—肿瘤]
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参考文献23

  • 1[1]OTERA H,OHSAKAYA S,NAGAURA Z,et al.Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space[J].EMBO J,2005,24(7):1375-1386.
  • 2[2]DELETTRE C,YUSTE V J,MOUBARAK R S,et al.AIFsh,a novel apoptosis-inducing factor (AIF) pro-apoptotic isoform with potential pathological relevance in human cancer[J].J Biol Chem,2006,281(10):6413-6427.
  • 3[3]KLEIN J A,LONGO-GUESS C M,ROSSMANN M P,et al.The harlequin mouse mutation downregulates apoptosis-inducing factor[J].Nature,2002,419(6905):367-374.
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  • 5[5]CREGAN S P,DAWSON V L,SLACK R S.Role of AIF in caspasedependent and caspase-independent cell death[J].Oncogene,2004,23(16):2785-2796.
  • 6[6]YUSTE V J,MOUBARAK R S,DELETTRE C.Cysteine protease inhibition prevents mitochondrial apoptosis-inducing factor (AIF) release[J].Cell Death Differ,2005,12(11):1445-1448.
  • 7[7]MUNOZ-PINEDO C,CARRION A G,GOLDSTEIN J C.Different mitochondrial intermembrane space proteins are released during apoptosis in a manner that is co-ordinately initiated but can vary in duration[J].Proc Natl Acad Sci USA,2006,103(31):11573-11578.
  • 8[8]MODJTAHEDI N,GIORDANETTO F,MADEO F,et al.Apoptosis inducing factor:vital and lethal[J].Trends Cell Biol,2006,16(5):264-272.
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医学分子生物学杂志
2008年 第1期

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