Ku80在鼻咽癌中的表达及其临床意义

Expression and Clinical Significance of Ku80 in Nasopharygeal Carcinoma

目的:探讨Ku80在鼻咽癌中的表达及其临床意义。方法:采用免疫组化SP法检测223例鼻咽癌石蜡标本中DNA-PK的三个亚基Ku80的表达情况,并结合患者的临床及预后资料分析其相关性。结果:Ku80在鼻咽癌组织中的过表达率为44%。Ku80表达强弱与患者的性别、年龄、病理分型无显著相关(P>0.05),与TNM分期、N分期、M分期有关(P<0.05)。单因素Kaplan-Meier生存分析显示,Ku80过表达组总生存率低于低表达组,Ku80对总生存率的影响有趋势,但尚未达到统计意义(P=0.141)。结论:Ku80在大部分鼻咽癌组织中的均有表达;Ku80与鼻咽癌的转移行为有关;初步研究未发现Ku80表达与鼻咽癌预后存在显著相关性,但有必要扩大样本进一步深入研究。

Objective： To investigate the expression and clinical significance of Ku80 in Nasopharygeal Carcinoma（NPC）. Methods ： The expression of Ku80 protein in 223 specimens of NPC was detected by immunohistochemistry. The correlation of Ku80 expression with clinicopathologie features and progonisis of NPC was analyzed. Results ： The overexpression rate of Ku80 was 44%. The expression of Ku80 had no significant correlation with the sex, age and pathological type（ P 〉0.05 ） , but had significant correlations with TNM, N and M stage（P 〈 0.05）. Kaplan-Meier survival analysis suggested that the patieuts with Ku80 overexpression had lower overall survival rate, but difference between the two groups had no statistical significance（ P = 0. 141 ）. Conclusion： The expression of Ku80 is positive in the majority of NPC. Ku80 expression may be correlated with metastasis of NPC. Our preliminary study shows that no significant correlation is found between the expression of Ku80 protein and prognosis of NPC. More cases should be accumulated to carry on the further investigation.