超声波催化合成3-羟基-4-吡啶酮

Synthesis of Two 3-hydroxy-4-pyridinone Compounds Under Ultrasonic Irradiation

在超声波催化条件下,麦芽酚与苄基氯、胺反应快速地合成了1,2-二甲基-3-羟基-4-吡啶酮和1-乙基-2-甲基-3-羟基-4-吡啶酮,目标产物经IR,1HNMR光谱表征,并与常规合成方法进行了比较,证明该方法使反应时间缩短,产率提高。

1,2-dimethyl-3-hydroxy-4-pyridinone and 1-ethyl-2-methyl-3-hydroxy-4-pyridinone were synthesized from 3-hydroxy-2-methyl-4-pyranone （maltol） and benzyl chloride through three steps of reactions under ultrasonic irradiation. 2-methyl-3-benzyloxy-4-pyranone （1）,N-substituted-2-alkyl-3-benzyloxy-4-pyranone （2a,2b）,N-substituted-2-alkyl-3-hydroxy-4-pyranone （3a,3b） were synthesized with moderate to high yields （40%~91.55%）. The results show that comparing with the conventional thermal reaction,ultrasonic irradiation reaction enjoys very good activities for synthesizing pyridinone compounds. The target compounds were characterized by IR,1H NMR spectra.