格列美脲联用甘精胰岛素或中性鱼精蛋白锌胰岛素治疗2型糖尿病的疗效及安全性

Study on the efficacy and safety of glimepiride combined with insulin glargine (IG) or neutral protamine hagedorn's (insulin) (NPH) in the treatment of type 2 diabetic patients

目的探讨格列美脲联用甘精胰岛素治疗磺脲类药物继发性失效的2型糖尿病患者的疗效及安全性。方法50例口服降糖药血糖控制不理想的2型糖尿病患者随机分为甘精胰岛素治疗组(IG组)和鱼精蛋白锌胰岛素治疗组(NPH组),予睡前皮下注射胰岛素联合口服格列美脲治疗12周,比较两组疗效及安全性。结果治疗后两组FBG、2hBG、HbAlc均明显下降,但IG组低血糖事件明显少于NPH组(P<0.01)。结论格列美脲联用甘精胰岛素治疗2型糖尿病的方案安全有效,能减少低血糖事件的发生。

Objective To evaluate the efficacy and safety of glimepiride combined with insulin glargine （IG） or NPH in the treatment of type 2 diabetic patients with secondary failure to sulfonylureas. Methods 50 type 2 diabetic patients under unsatisfied blood glucose control were randomly divided into 2 groups,the IG treatment group and the NPH treatment group. They were treated by glimepiride with IG or NPH bedtime injection for 12 weeks,then the efficacy and safety of the two groups were compared. Results After treatment, the levels of FBG, 2hBG and HbA1c were decreased in the two groups, but the incidence of hypoglycemia in the IG group was significantly lower than that in the NPH group （ P 〈 0.01 ）. Conclusions Glimepiride with insulin glargine can control the blood glucose effectively in type 2 diabetic patients possessing low incidence of hypoglycemia and high safety.