人胰腺癌组织中R-ras的表达及其临床意义

Detection of R-ras gene expression in human pancreatic cancer and its clinical value

目的检测人类胰腺癌组织中R-ras的表达情况并探讨其临床意义。方法用免疫组织化学方法检测65例胰腺癌组织及癌旁组织中R-ras、P21ras和增殖细胞核抗原(PCNA)的表达,并对检测结果作统计学分析。结果胰腺癌组织中R-ras、P21ras和PCNA的阳性表达率均显著高于癌旁组织中的表达率(均P<0.01);R-ras阳性表达率与胰腺癌组织的病理分化程度无关(P>0.05);R-ras阳性表达率与P21ras和PCNA的阳性表达率均相一致(均P<0.01)。结论R-ras在原发性胰腺癌组织中表达增加,可能参与了胰腺癌的发病过程。

Objective To detect the expression of R-ras gene in primary pancreatic cancer tissue and to evaluate its clinical value. Methods The expression of R-ras, P21ras and PCNA were measured by immunohistolochemistry examination in pancreatic cancer tissue and pericancerous normal tissue of 65 cases of primary pancreatic cancer. Results Positive expression rates of R-ras, P21ras and PCNA in primary pancreatic cancer tissue were significantly higher than those in pericancerous normal tissue. There was no correlation of R-ras expression with the differentiation degree of tumor. There was no correlation of R-ras gene expression with that of P21ras and PCNA in pancreatic cancer tissue. Conclusion The expression of R-ras gene is elevated in human primary pancreatic cancer tissue.