二正丁基锡(Ⅳ)-邻菲咯啉-单核苷酸混配配合物的合成与表征

Synthesis and Characterization of Mixed-ligand Di-n-Butyltin(IV) Complexes of Phenanthroline and Nucleotides

本文研究了二正丁基邻菲咯啉二氯锡(Ⅳ)(n-Bu)_2SnCl_2(Phen)与单核苷酸(Nu)在近生理pH水溶液中的作用,结果表明,二正丁基邻菲咯啉二氯锡(Ⅳ)的一个顺氯原子被单核苷酸取代,得到了(n-Bu)_2Sn(phen)(Nu)Cl型混配新配合物,单核苷酸以磷酸根氧原子与锡(Ⅳ)键合,并给出了其结构.

The reactions between the antitumor agent (n -Bu)2SnCl2 (phen) (phen = phenanthroline) and nucleotides result in the formation of mixed- ligand complexes formulated as (n -Bu)2Sn(phen)(Nu)Cl (where Nu is 5' -AMP, 5' - CMP and 5' - GMP), in which there is a monodentate coordination of Sn( IV) to oxygen atom of phosphate groups as characterized by 500MHz 1H,31P NMR and FT- IR. The possible structure of these complexes is proposed.