毛细管电泳对取代四氢-β-咔啉类手性化合物的定量分析

Quantitative Analysis of Substituted Tetrahydro-β-Carboline Chiral Compounds by High Performance Capillary Electrophoresis

将ＨＰＣＥ作为不对称合成产物取代四氢－β－咔啉类手性化合物的对映体纯度测试手 段，对其定量分析能力进行考察，得到的线性相关因子为０.９９７；检测限为 ０.５×１０－６ｇ／ｇ；相 对峰面积的相对标准偏差小于１％；相对迁移时间的相对标准偏差小于０．１％。

The ability of HPCE as an analytical approach for optical purity determination of enantiomers was investigated using substituted tetrahydro-β-carboline chiral compounds as test substances. Good linearity, low detection limit and fine precision were obtained.