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放线菌次生代谢产物合成基因组研究 被引量:4

Synthetic Genome of Secondary Metabolites of Actinomyces
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摘要 简述放线菌全基因组研究概况,次生代谢产物合成基因组研究涉及的问题;重点介绍聚酮类化合物合成基因组的结构和功能;如何利用基因组筛选程序,筛选具有生物活性次生代谢产物合成基因簇的产生菌,作为新药发现的一种手段。 Brief account of the study on omni-genome and problems involved in genes of secondary metabolites synthesis of Actinomycetes were reviewed.Introduction to structure and function of polyketide genes,and how to screen strains possessing gene clusters that enable to produce bioactive secondary metabolites by utilizing genome-screening procedure as a means to discover new medicine were stressed.
出处 《微生物学杂志》 CAS CSCD 2007年第6期68-71,共4页 Journal of Microbiology
基金 国家重大基础研究发展规划项目(973项目 2004CB719601) 国家自然科学基金项目(30560001 30600001) 云南省国际合作计划项目(2005GH21) 国家科技部国际合作项目(2006DFA33550)资助
关键词 放线菌 次生代谢产物 基因组 Actinomycetes secondary metabolites genome
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参考文献9

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