幽门螺杆菌感染与心房颤动的相关性研究

Relationship between helicobacter pylori IgG seropositivity and atrial fibrillation

目的探讨幽门螺杆菌感染与心房颤动的关系。方法用酶联免疫（ELISA）法检测心房颤动组（101例）和非心房颤动组（53例）血浆幽门螺杆菌抗体（Hp IgG）；用酶联免疫法和放射免疫法，测定心房颤动组血清超敏C反应蛋白（hs—CRP）、内皮素-1（ET-1）、醛固酮（ALD）含量，并测量左心房内径。结果心房颤动组血清幽门螺杆菌抗体阳性率（46．5％，47／101）明显高于非心房颤动组（26.4％，14／53）（P〈0.05）；心房颤动合并慢性幽门螺杆菌感染者hs-CRP、ET-1、ALD水平均较非幽门螺杆菌感染者明显升高（P〈0．01），左心房内径亦明显增大（P〈0．01）；慢性幽门螺杆菌感染与年龄、性别、心房颤动家族史、饮酒史、肥胖史、高脂血症等无关。结论慢性幽门螺杆菌感染与心房颤动有关，可能是心房颤动的独立危险因素；心房颤动合并慢性幽门螺杆菌感染者hs-CRP、ET-1水平明显升高，左心房内径亦明显增大，慢性幽门螺杆菌感染可能是心房颤动的发病机制之一。

Objective To investigate the relationship between helicobaoter pylori（Hp） and atrial fibrillation （AF） ,and the role of Hp in the mechanism of atrial fibrillation. Methods Hp IgG was measured in total 101 cases of atrial fibrillation（AF） and 53 healthy subjects, High-sensitivity C-reactive protein（hs-CRP）, endothelin-1 （ET-1）, adlosterone（ALD） ,inside diameter of left atrium were measured in 101 cases of atrial fibrillation（AF）. Results The rate of seropositive for Hp IgG in AF patients is significantly higher than that of controls （P 〈 0. 05）, the level of high-sensitivity C-reactive protein（hs-CRP）, endothelin-1 （ ET-1 ）, adlosterone （ALD）, inside diameter of left atrium in these of Hp IgG seropositive is higher than that of Hp seronegativity（P〈0.01） and there was no correlation between chronic Hp infection and essential hypertension , tobacco use, age, gender, alcohol eonsumption, family history and hyperlipidemia. Conclusion The above alterations might be the mechanlsm that Hp contribute to the pathogenesis of atrial fibrillation; there was no correlation between chronic Hp infection and essential hypertension, tobacco use, age, gender, alcohol consumption, family history and hyperlipidemia. For this reason, chronic Hp infection might be one of risk factors of atrial fibrillation.