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胰岛素样生长因子及其受体在不同分期非小细胞肺癌中的表达和意义 被引量：1

Expressions of IGF-Ⅰ, IGF-Ⅱ, IGF-ⅠR in non-small cell lung cancer of different TNM stages
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摘要 目的探索胰岛素样生长因子（IGF—Ⅰ、IGF-Ⅱ）及其受体（IGF—ⅠR）在不同TNM分期非小细胞肺癌（NSCLC）中的表达和意义。方法对30例NSCLC中IGF—Ⅰ、IGF-Ⅱ、IGF—ⅠR的表达进行免疫组织化学检测，探讨其表达水平与肺癌分期的关系。结果IGF—Ⅰ、IGF-Ⅱ、IGF—ⅠR在30例NSCLC组织中呈现阳性表达，且表达水平与肺癌的分期密切相关．相邻分期之间IGF—Ⅰ、IGF-Ⅱ、IGF—ⅠR表达水平的差异有统计学意义。结论IGF—Ⅰ、IGF-Ⅱ、IGF—ⅠR在肺癌的恶性进展方面具有重要意义，可作为评估NSCLC进展的有价值的指标。 Objective To explore the expression and significance of IGF-Ⅰ, IGF-Ⅱ, IGF-ⅠR in NSCLC of different TNM stages. Methods The expression of IGF-Ⅰ, IGF-Ⅱ, IGF-ⅠR in 30 cases of NSCLC was detected with immunohistochemical methods, and to explore the relationship between the expression of IGF-Ⅰ, IGF-Ⅱ, IGF-ⅠR and the TNM stages were analyzed. Results IGF-Ⅰ, IGF-Ⅱ, IGF-ⅠR expressions varied in different stages with significant difference between each stage（P 〈 0.05）. Conclusion The detection of IGF-Ⅰ, IGF-Ⅱ, IGF-ⅠR protein might be significant to evaluate the malignant potential in lung cancer,and plays certain roles in staging and prognosis evaluation.
作者 杨泳 潘铁成 尹杰
机构地区 武汉市第一医院胸心外科 华中科技大学同济医学院附属同济医院胸心外科
出处 《中国基层医药》 CAS 2008年第1期41-43,I0001,共4页 Chinese Journal of Primary Medicine and Pharmacy
关键词 生长调节素类 受体 生长调节素类 癌 非小细胞肺 Somatomedins Receptors, somatomedin Carcinoma, non-small- cell lung
分类号 R734.2 [医药卫生—肿瘤]
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参考文献6

  • 1Lippman SM, Spitz MR. Lung cancer chemoprevention: an integrated approach. J Clin Oneol,2001,19(18) :74s-82s.
  • 2Chen H, Yan GC, Gishizky M. Identification of structural characteristics that contribute to a antiapoptotic function between human insulin-like growth factor- Ⅰ receptors- Cell Growth Differ, 1998,9(11):939-947.
  • 3Minuto F, Del Monte P, Barreca A, et al. Evidence for an increased sOmatomedin-C/insulin-like growth factor-Ⅰ content in primary human lung tumors. Cancer Res, 1986,46 (5) :985-988.
  • 4Kaiser U, Schardt C, Brandscheidt D, et al. Expression of insulinlike growth factor receptor Ⅰ and Ⅱ in normal human lung and in lung cancer. J Cancer Res Clin Oncol, 1993,119(10) : 665-668.
  • 5Quinn KA, Treston AM, Unsworth EJ, et al. Insulin-like growth factor expression in human cancer cell lines. J Biol Chem, 1996, 271(19):11477-11483.
  • 6Takanami I, Imarnuma T, Hashizume T, et al. Expression of PDGF, IGF- Ⅱ , bFGF and TGF-beta 1 in pulmonary adenocarcinoma. J Surg Oncol, 1996,61 (3) : 205.

同被引文献22

  • 1Durai R,Yang W, Gupta S, et al. The role of the insulin-like growth factor system in colorectal cancer: review of current knowledge. Int J Colorectal Dis ,2005,20 (3) :203-220.
  • 2Wesley UV, McGroarty M, Homoyouni A. Dipeptidyl peptidase in- hibits malignant phenotype of prostate cancer cells by blocking basic fibroblast growth factor signaling pathway. Cancer Res, 2005,65 (4) : 1325 -1334.
  • 3LeRoith D, Roberts CT Jr. The insulin-like growth factor system and cancer. Cancer Lett,2003,195(2) :127-137.
  • 4Castillo SS. A possible role of insulin-like growth factor-Ⅱ C-pep- tide in regulating the function of steroidogenic cells in adult frog adrenal glands. Acta Histochem,2008,110 ( 6 ) :451-461.
  • 5Codina M, Garcia de la sermna D, Sanchez-Gurmaches J, et al. Metabolic and mitogenic effects of IGF-Ⅱ in rainbow trout ( On- corhynchus mykiss)myocytes in culture and the role of IGF-II in the PI3K/Akt and MAPK signalling pathways. Gen Comp Endo- crinol,2008,157 (2) :116-124.
  • 6Kalla Singh S,Tan QW, Brito C, et al..Insulin-like growth factors Iand Ⅱ receptors in the breast cancer survival disparity among Af- rican-American women. Growth Horm IGF Res, 2010,20 ( 3 ) : 45 -54.
  • 7Bemont I, Lamielle F, Fauconnel S, et al, Regulation of vascular endothelial growth factor expression by insulin-ike growth factor in cndometrical adenocarcinoma cells. Int J Cancet, 2000, 85 (1) :117-123.
  • 8Brodt P, Fallavollita L, Khatis AM, et al. Cooperative regulation of the invasive domains of the type I insulin-like growth factor re- ceptor beta subunit. J Biol Chem ,2001,276(36) :33608-33615.
  • 9Ali MA. Lymphatic microvessel density and the expression of lym- phangiogenic factors in oral squamous cell carcinoma. Med Princ Pract,2008,17 (6) :486-492.
  • 10Bjomdahl M, Cao R,Nisscn LI, et al. lnsulin-likc growth factors 1 and 2 induce lymphangiogcncsis in vivo. Proc Natl Acad Sci U S A ,2005,102(43) : 15593-15598.

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中国基层医药
2008年 第1期

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