SD大鼠实验性缺血性脑水肿的MRI研究

MRI of Experimentel Cerebral Ischemic Edema in SD Rats

通过MRI对大鼠急性缺血性脑水肿进行评价。材料和方法：27只SD大鼠闭塞左侧中动脉后4小时至7天行MRI检查。结果：脑血管闭塞后MRI发现脑梗塞的最早时间为6小时，表现为T2WI局灶性高信号，梗塞后6－24小时T2WI信号强度进行性增高，与正常组织比较，信号强度增加率从45％发展到65％，占位效应于梗塞后72小时达到高峰。结论：MRI可以作为缺血性脑水肿的早期诊断方法。

The evolution of arute cerebral ischemic edema was documented by MRI in rats. Materials andMethods: 27 Spragur - Dawley rats were subected to permanent unilateral occlusion of the left middlecerebrai arteries followed by MRI from 4 hours to 7 days. Results: The earliest finding of infarction wasseen at 6 hour as an area of high signal intensity on T2 - weighted imangs. Presenting a progressive increase intensity of the infarct between 6 and 24 hour, rearhing from 45% to 65% above that of the normaltissue singnal intensity. The mass effcet of the infarction appeared greatest at 72 hour after the attact. Conclusion: MRI am be recommended as a nearly diagnostic tool for the detection of cerebral ischemia edema.