微血管量在浸润性乳腺癌中的意义

THE VALUE OF MICROVESSEL DENSITY IN INVASIVE BREAST CARCINOMA

探讨微血管量在浸润性乳腺癌中的意义。方法应用亲和素－生物素－过氧化物酶复合物（ＡＢＣ）免疫组织化学方法对７０例乳腺浸润性导管癌作荆豆素（ＵＥＡ１）和第八因子（Ｆ８）染色，并对癌组织中的微血管计数。采用Ｌｏｇｉｓｔｉｃ多因素回归分析法进行分析。结果淋巴结有转移组和无转移组间微血管计数有极显著的差异（Ｐ＜０．０００１）。淋巴结有转移组的微血管密度显著高于无淋巴结转移组（Ｐ＜０．０００１）。肿瘤的组织学分级与微血管计数及淋巴结转移显著相关（Ｐ＜０．０５和Ｐ＜０．０００１）。术后健在组患者和带癌生存、死亡组患者的微血管计数有显著差异（Ｐ＜０．０５）。结论浸润性乳腺癌内的微血管量是一个独立的有重要意义的预后因素，与淋巴结转移、患者的生存状况密切相关。

PURPOSE To study the value of microvessel density in invasive breast carcinoma. METHODS The expression of UEA1 and F8 was immunohistochemically detected by ABC method in 70 cases of primary invasive ductal carcinoma. RESULTS Multivariate analysis showed significant differences in microvessel density between patients with and without axillary lymph node metastasis. Patients with lymph node metastasis had increased microvessel density ( P <0.0001). There was signification association between histological grading and microvessel density and lymph node metastasis( P <0 05 and P <0 0001) There was a statistically significant difference in microvessel density between patients who were disease free and those who were not( P <0 05) CONCLUSIONS Microvessel density is an important and independent prognostic parameter for invasive breast carcinoma. Increased microvessel density is associated with lymph node metastasis and reduced survival.