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人胃腺癌TIL培养上清中sIL-2R及IFN-γ含量变化与抑瘤观察 被引量:2

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摘要 胃癌是我国发病率最高的恶性肿瘤之一,以腺癌居多.胃癌肿瘤浸润淋巴细胞(TIL)的研究及应用尚不多见.本文自2例人胃腺癌引流淋巴结中分离培养TIL细胞,动态观察其培养上清中sLL-2R及IFN-γ含量的变化,并探讨含量变化与TIL上清体外抑瘤活性变化的内在关系.
出处 《中国肿瘤生物治疗杂志》 CAS CSCD 1997年第2期152-153,共2页 Chinese Journal of Cancer Biotherapy
基金 本工作受福建省科委95J13项目资助
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同被引文献6

  • 1刘振华,蓝兰,林秋华,王清水.自体可溶性肿瘤抗原协同IL-2诱导外周血PBMC增殖及杀瘤[J].肿瘤,1997,17(S1):46-47. 被引量:4
  • 2Okamoto M,Ohe G,Furichi S,et al.Enhancement of anti-tumor immunity by lipoteichoic acid-related molecule isolated from OK-432,a streptococcal agent,in athymic nude mice bearing human salivary adenocarcinoma:role of natural killer cells.Anticancer Res,2002,22(6):3229~3239.
  • 3Salio M,Cella M,Vermi W,et al.Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions.Eur J Immunol,2003,33(4):1052~1062.
  • 4Yamamoto T,Kimura T,Ueta E,et al.Characteristic cytokine generation patterns in cancer cells and infiltrating lymphyocytes in oral squamous cell carcinomas and the influence of chemoradiation combined with immunotherapy on these patterns.Oncology,2003,64(4):407~415.
  • 5Kass R,Bellone S,Palmieri M,et al.Restoration of tumor-specific HLA class I restricted cytotoxicity in tumor infiltrating lymphocytes of advanced breast cancer patients by in vitro stimulation with tumor antigen-pulsed autologous dendritic cells.Breast Cancer Res Treat,2003,80(3):275~285.
  • 6刘振华,蓝兰,林秋华,王清水.胃腺癌TIL体外培养高效扩增体系的建立——应用自体LAK上清和GM-CSF[J].肿瘤,1998,18(1):41-42. 被引量:2

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