有氧运动对大鼠血清瘦素水平(Leptin)的影响

Effects of Aerobic Exercise on Serum Leptin in Rats

为探讨有氧运动对大鼠血清中瘦素(1eptin)含量的影响及变化的时相性,把SD(Sprague-Dawley)大鼠分为安静对照组(C)和有氧运动后即刻组(T0)、24 h组(T1)、48 h组(T2)、72 h组(T3)进行比较性研究。结果发现:与安静对照组相比,6周有氧跑台运动后,T0、T1、T2、T3组体重、体重增加量均显著低于对照组(前者P<0.01,后者P<0.05),双侧附睾脂肪垫重量显著低于对照组(P<0.05);血清瘦素含量,T1、T2、T3组显著下降(P<0.01),T0组有下降趋势,但不具有显著性差异(P>0.05)。各组下降的幅度分别为4%、20%、42%、15%,其中,T2组下降最明显。有氧运动各组相比,T2与T0组相比显著下降(P<0.01),T2与T1组相比显著下降(P<0.05),T3与T2组相比显著升高(P<0.01)。结论:有氧运动能够减少大鼠体重、体重增加量和腹部脂肪积累,调节脂代谢,防止肥胖和高脂血症的作用;降低血清Leptin水平,而且Leptin水平的下降具有时相性,可能是由于最后一次运动所产生的延迟作用造成的;体内Leptin含量下降与体脂减少密切相关,正常生理状态下运动降低血清瘦素水平是机体为维持自身体重稳定和能量平衡的一种适应性反应。

In order to analyze the phase of the effects of aerobic exercise on serum leptin in rats, the author makes the comparative analysis of sedentary control group （C） and after they has performed exercise training program immediately （T0）, and in 24 （T1）, 48 （T2）, 72 hours （T3） respectively. The results showed that the body weight, increment and weight of epididymal fat pads of T0, T1, T2, T3 were markedly lower than sedentary control group after aerobic exercise （p〈0.01, p〈0.05）; the serum leptin of T1, T2, T3 was significantly lower than control rats （P〈0.01）, but the serum leptin of TO is lower （P〉0.05）. Each descendent range is 4%, 20%, 42%, 15% respectively, but the descendent range of T2 is obvious mostly. In aerobic exercise group, the serum leptin of T2 is significantly lower than TO and T1 （p〈0.01, p〈0.05）, the serum leptin of T3 is markedly higher than T2 （p〈0.01）. The results showed that the regulax aerobic exercise have the function of reducing the body weight, increment and weight of epididymal fat pads, improving the lipid metabolism, preventing the rotundity and high blood fat. The regular aerobic exercise can reduce serum leptin and have the phase, it can be the delaying impact for the aerobic ex- ercise at last; there has obvious relation with serum leptin and body fats, Under normal physiological condition decreased serum leptin level by aerobic exercises is an adaptive reaction to maintain stable body weight and balanceable energy.