摘要
以磷酸锌钾为催化剂,催化苯甲醛与氰乙酸乙酯进行Knoevenagel缩合反应。用熔点测定仪、IR、GC-MS表征了缩合产物,结果表明缩合产物为α-氰基肉桂酸乙酯。产物的总产率为85.6%,其中反式产物与顺式产物的比例分别为98.2%和1.8%。实验结果表明,磷酸锌钾无须负载任何物质,其本身就是一种催化芳香醛和活泼亚甲基化合物发生Knoevenagel缩合反应的良好催化剂,该反应可在温和的条件下高效地进行,产品产率高,纯度好,操作和后处理简单方便。
Potassium zinc phosphate was used as the catalyst for Knoevenagel condensation of benzaldehyde with ethyl cyanoacetate.The products were characterized by melting poiot,IR and GC-MS.The characteristics results indicated that the products were ethyl α-cyanocinnamates with the total yield 85.6%,the trans-one and cis-one of the products were 98.2% and 1.8%,respectively.The experimental results showed that potassium zinc phosphate without loading anything was a good catalyst for Knoevenagel condensation of aromatic aldehydes with active methylene compounds.The condensation was reacted efficiently at mild condition, the yield and purity were good,and the reaction procedure was simple.
出处
《化工技术与开发》
CAS
2008年第1期1-3,共3页
Technology & Development of Chemical Industry
基金
教育部科研重点项目(205120)
广西科学基金(桂科基0575006)
广西测试基金(2006年)