磷酸锌钾催化Knoevenagel缩合反应

Knoevenagel Condensation Catalyzed by Potassium Zinc Phosphate

以磷酸锌钾为催化剂,催化苯甲醛与氰乙酸乙酯进行Knoevenagel缩合反应。用熔点测定仪、IR、GC-MS表征了缩合产物,结果表明缩合产物为α-氰基肉桂酸乙酯。产物的总产率为85.6%,其中反式产物与顺式产物的比例分别为98.2%和1.8%。实验结果表明,磷酸锌钾无须负载任何物质,其本身就是一种催化芳香醛和活泼亚甲基化合物发生Knoevenagel缩合反应的良好催化剂,该反应可在温和的条件下高效地进行,产品产率高,纯度好,操作和后处理简单方便。

Potassium zinc phosphate was used as the catalyst for Knoevenagel condensation of benzaldehyde with ethyl cyanoacetate.The products were characterized by melting poiot,IR and GC-MS.The characteristics results indicated that the products were ethyl α-cyanocinnamates with the total yield 85.6%,the trans-one and cis-one of the products were 98.2% and 1.8%,respectively.The experimental results showed that potassium zinc phosphate without loading anything was a good catalyst for Knoevenagel condensation of aromatic aldehydes with active methylene compounds.The condensation was reacted efficiently at mild condition, the yield and purity were good,and the reaction procedure was simple.