幽门螺杆菌释放的小分子多肽对胃黏膜的损伤作用

Damage of small macular multi-peptides which secreted by helicobacter pylori to gastric mucosa

幽门螺杆菌(Hp)是人类最常见的致病菌之一,与慢性胃炎、消化性溃疡、肠上皮化生、胃癌、黏膜相关性淋巴样组织(MALT)淋巴瘤等密切相关。Hp对胃黏膜的损伤作用有3方面的因素:一、宿主因素,它决定最终临床感染结果;二、自身因素,如Hp表面及释放入血的小分子多肽等;三、环境因素,如营养状况等。Hp释放的小分子多肽对胃黏膜的损伤作用是Hp的致病机制之一。

Helicobacter pylori （Hp） is one of the most common pathogenic Bacterium which has close correlation with chronic gastritis, peptic ulcer diseases, intestinal metaplasia, gastric carcinoma, mucosa-associated lymphoid tissue（MALT） lymphoma. There are three damage factors of Hp to gastric mucosa： The first is host genetic factors, which plays a role in determine the clinical outcome of the infection; the second is Hp virulence factors which also has pathological effects such as the small macular multi-peptides which express in the out membrane of Hp or secrete to the blood stream; the third is environmental factors such as nutritions which also be thought important. One of pathogenic mechanism of Hp is the damage of small macular multi-peptides which secreted by Hp to gastric mucosa.