微生态失衡与炎症性肠病

Intestinal dysbiosis and inflammatory bowel disease

炎症性肠病(IBD)包括克罗恩病(CD)和溃疡性结肠炎(UC),其病因和发病机制目前尚不清楚。研究发现,肠道微生态失衡即肠道致病菌和益生菌之间的平衡失调,在IBD的发生和发展中发挥重要作用。此文就微生态失衡在IBD发病中的作用作一综述。

Inflammatory bowel disease（IBD） includes ulcerative colitis（UC） and Crohn＇s disease（CD）. The pathophysiology mechanisms of the disease remains elusive. Abundant data have incriminated intestinal bacteria in the initiation and development stage of IBD. It is presumed that there is a breakdown in the balance between protective and harmful intestinal bacteria, namely dysbiosis. Here we will review the relationship between intestinal dysbiosis and IBD.