胰高血糖素样肽-2与炎症性肠病

Glucagon-like peptide-2 and inflammatory bowel disease

炎症性肠病(IBD)是一组病因不明的慢性肠道炎症性疾病。胰高血糖素样肽-2(glucagon-like peptide-2,GLP-2)是胰高血糖素原(PG)基因的表达产物之一,近年来发现GLP-2具有促进肠黏膜增长、抑制炎性介质表达的作用,这可能为炎症性肠病的治疗开辟新的途径。

Inflammatory bowel disease is a group disease of chronic intestinal inflammation whose causes is still unknown. Glucagon-like peptide-2 is one of expressions of proglucagon gene. Recently it is found that GLP-2 could enhance the stimulation of intestinal mucosal proliferation, reduce the inflammatory mediator＇s expression. This may be creat a new way to cure IBD.