卵巢癌中紫杉醇耐药机制与克服耐药策略的研究进展

Taxol resistance in ovarian cancer and its management

化疗耐药是卵巢癌复发的主要原因,严重影响患者的预后。紫杉醇是卵巢癌化疗的一线用药之一,因此,有关紫杉醇耐药的机制和克服耐药的策略得到了广泛而深入的研究。本文简要介绍了近年来有关紫杉醇耐药和克服耐药策略的研究进展。

Chemotherapy resistance is the main reason for the recurrence of ovarian cancer and leads to a poor prognosis. Taxol is one of the most important agents in the first-line chemotherapy for ovarian cancer. The mechanisms of taxol resistance and it manegement strategies have been widely studied, as briefly reviewed in this article