左旋沙丁胺醇抑制豚鼠气道平滑肌收缩的实验研究

The experimental research of R-Salbutamol on inhibiting the contraction of isolated tracheal smooth muscle in guinea-pig

目的评价左旋沙丁胺醇(R-Salbutamol,R-Sal)对组胺(histamine,His)诱发的豚鼠离体气管条和肺条收缩功能的影响。方法制备豚鼠离体气管条和肺条标本,以定量药理学方法测定10-8、10-7、10-6mol·L-1剂量的R-Sal孵育前后对His诱发的离体标本的收缩反应的舒张作用,并与10-6mol·L-1剂量的Sal进行比较。结果R-Sal可显著抑制His所引起的豚鼠离体气管和肺条的收缩反应,呈剂量依赖性,其作用强于Sal(P<0.01)。结论R-Sal对His诱发的豚鼠离体气管条和肺条的收缩反应具明显的舒张作用。

Aim To evaluate the effects of R-Salbutamol （R-Sal） on the contraction of isolated tracheal strips and lung parenchyma strips in guinea-pig, induced by Histamine（His）. Methods Tracheal strips and lung parenchyma strips of guinea-pig in vitro were prepared, and the dilatory effect on shrinkage reaction of isolating specimens induced by His were measured before or after the administration of R-Sal in doses of 10 ^-8, 10 ^-7 10^-6 mol · L^-1, with fix-doses pharmacology methods. The inhibitory effect was compared with that of Sal （10-6 mol · L^-1 ）. Results His could induce the contraction of isolated strips in guinea-pig in a dose-dependent manner, and R-Sal could significantly inhibit this shrinkage of lung parenchyma induced by His. in a dose-dependent manner. R-Sal was much more efficient than Sal（P 〈0. O1 ） in its inhibitory effect. Conclusions R-Sal has a significant dilatory effect on the contraction reaction of isolated tracheal strips and lung parenchyma strips in guinea-pig induced by His.