摘要
目的探讨苯丙胺对大鼠行为及其血清IL-2的影响。方法雄性SD大鼠60只(80～100g)随机分为低剂量组(0.5mg/kg苯丙胺)、中剂量组(2.5mg/kg苯丙胺)、高剂量组(5.0mg/kg苯丙胺)和对照组,肌肉注射苯丙胺,观察不同处理后大鼠的行为变化,用ELISA法检测血清IL-2的含量。结果①大鼠刻板行为评分,注射生理盐水的对照组无异常反应,不同剂量的用药组明显高于对照组(P<0.05);②用药组3个剂量大鼠血清IL-2的含量与对照组相比差异无统计学意义(P>0.05)。结论提示本实验剂量的苯丙胺对大鼠有神经毒性,但对大鼠血清IL-2没有明显影响。
Objective To investigate the influence of amphetamine on behavior and serum level of IL-2 of rats. Methods Forty five mail SD rats （80-100 g） received intramuscular injection of amphetamine and were divided into low dose group （0.5 mg/kg）, middle dose group（2.5 mg/kg） and high dose group（5.0 mg/kg）. Fifteen rats were match as control group. Behavior. changes were observed and score was evaluated according to Sams-Dodd method and serum level of IL-2 was measured by ELISA. Results （1） Stereotyped behavior score showed no significant difference in control group compared to normal rats but was significantly higher in the experimental group than that of the control group （P〈0.05）. （2） Serum IL-2 level in the experimental group has no statistical significance compared to the control group. Conclusion Amphetamine has neurotoxicity on the experiment rats, but no significant inflluence on serum IL-2 level of rats .
出处
《解剖学研究》
CAS
2008年第1期44-46,共3页
Anatomy Research
